Respiratory tract infections: Acute and Chronic bronchitis, Pneumonia, Pneumocystis carinni pneumonia, Pneumonitis, Pharyngitis, Tonsillitis, Sinusitis, Otitis media. Urinary tract infections: Acute and Chronic Cystitis, Pyelonephritis, Urethritis. Gastrointestinal tract infections: These include Typhoid and Paratyphoid fever, Typhoid carrier state and bacillary dysentery and cholera. Skin and soft tissue infections: Pyoderma, Furuncles, abscesses and infected wounds. Bacterial infection: Acute and Chronic Osteomyelitis, acute brucellosis, Septicaemia due to sensitive organisms, norcardiosis, mycetoma (except when caused by fungi), South American blastomycosis. In patients with impaired renal function, the dosage should be reduced or the interva between doses prolonged inorder to prevent accumulation in the blood. Determination of plasma drug concentration is recommended in such patients. Regular blood counts are advisable whenever Emtrim is given for prolonged period especially in the elderly, with possibility of haematological changes indicative of folic acid deficiency, these are reversible by folic acid therapy. An adequate urinary output should be maintained at all times. Treatment must be discontinued immediately a skin rash appears.